First draft prepared

Explanation.................................................................................................. 256 Evaluation for acceptable daily intake......................................................... 256 Biochemical aspects............................................................................... 256 Absorption, distribution, and excretion ................................................. 256 Biotransformation.................................................................................. 258 Effects on enzymes and other biochemical parameters ......................... 260 Toxicological studies ............................................................................. 260 Acute toxicity ........................................................................................ 260 Oral administration Dermal application ..................................................................... 262 Exposure by inhalation ............................................................... 262 Intraperitoneal administration..................................................... 262 Skin irritation.............................................................................. 262 Eye irritation............................................................................... 263 Skin sensitization........................................................................ 263 Local lymph node assay in mice................................................. 264 Short-term studies of toxicity ........................................................... 264 Oral administration ..................................................................... 264 Dermal application ..................................................................... 275 Exposure by inhalation ............................................................... 276 Long-term studies of toxicity and carcinogenicity ........................... 278 Genotoxicity ..................................................................................... 283 Reproductive toxicity ....................................................................... 285 Multigeneration study................................................................. 285 Developmental toxicity............................................................... 287 Special studies .................................................................................. 290 Plasma kinetics ........................................................................... 290 Physiological functions............................................................... 291 Study of acute neurotoxicity in rats ............................................ 292 Studies with metabolites ............................................................. 293 Observations in humans......................................................................... 293 Comments.................................................................................................... 293 Toxicological evaluation ............................................................................. 295 References ................................................................................................... 298 ..................................................................... 260